REGULATORY ELEMENTS AND THEIR EVOLUTION
Enhancers are DNA elements that are spatial temporal integrators of gene expression. Enhancers evolve rapidly – most tissue-specific human enhancers cannot be mapped in the mouse. We use a wide range of computational and molecular approaches to understand their mechanisms of function and mode of change.
NON-PROTEIN CODING MUTATIONS IN HEART DISEASE
Most disease loci lie in non-coding regions of the genome and are enriched at enhancers and promoters. We use functional approaches to study how enhancers are encoded in the heart and how they are disrupted in disease.
GENETICS AND EPIGENETIC OF AGEING
We use single cell multi-omics approaches to study the genetics and epigenetic of how tissues change in ageing animals. This work is done in collaboration with Profs Tuomas Tammela and Lee Jones at MSKCC (NY, USA).
REGENERATION AND DEVELOPMENT
We are studying the systems biology of heart regeneration to better understand the restorative mechanisms of cells in damaged hearts in vertebrates. Regeneration has been studied in a range of animals but the zebrafish is the most extensively-studied vertebrate model for heart regeneration. We use quantitative strategies to understand how regulatory systems change during the repair process.